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KMID : 0897520210260010001
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Journal of Korean Association of Social Psychiatry
2021 Volume.26 No. 1 p.1 ~ p.11
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Systematic Review about the Role of Physical Activity for Functional Improvement of Patients with Schizophrenia
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Seo Young-Eun
Shin Jae-Gwon
Choi Jong-Hyuk
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Abstract
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Objectives : Schizophrenia which commonly occurs at early adulthood causes great socioeconomic burdens. Schizophrenia is featured by chronic cognitive impairment and persistent functional disability. And patients with schizophrenia is vulnerable to metabolic syndrome and its comorbidity. Atypical antipsychotics and various psychosocial interventions are helpful with the recovery, yet their efficacy is limited in aspects of cognitive impairment and functional disability. Regular aerobic exercise is known to improve brain function with various mechanisms like neurogenesis, angiogenesis, and synaptogenesis. So it is plausible that aerobic exercise might exert its therapeutic effect on schizophrenia. We have searched the studies related to this issue.
Methods : We conducted a search of Pubmed and Google Scholar to identify articles relating to therapeutic effects of aerobic exercise in schizophrenia. We focused on the articles that examined the impact on cognitive impairment in schizophrenia using MATRICS Consensus Cognitive Battery (MCCB). And we also included the studies which utilized clinician-rated instruments on cognitive, functional, or clinical domain. We excluded the articles that examined benefits of yoga or tai-chi only and failed to present the dose of exercise intervention.
Results : We identified 11 articles that examined the impact of aerobic exercise on cognitive impairment in schizophrenia. 9 of them also examined change of clinical symptoms, and 7 of them showed significant improvement. 6 articles examined functional recovery and 4 of them showed significant improvement. 8 of 11 studies identified significant improvement of cognition, especially on working memory, social cognition, and verbal learning subsets. Some studies proved correlation between biological change and clinical improvement.
Conclusion : Aerobic exercise can improve clinical and cognitive symptoms in schizophrenia, thus enhance level of functioning. However further investigation is warranted to determine the adequate dose and type of exercise for therapeutic purpose.
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KEYWORD
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Schizophrenia, Cognitive impairment, Functional disability, Recovery
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